Gout is a common type of arthritis that causes inflammation, swelling and pain of the joints. The disease is caused by the accumulation of uric crystals at the level of the joints and muscular tissues. In many cases, the underlying cause of gout is high serum uric acid concentration. Uric acid is a substance synthesized during the bodys purine metabolism, having no physiological importance inside the organism. In fact, uric acid is a waste product excreted by the kidneys through urine. High serum uric acid levels are the result of either overproduction or inappropriate excretion of uric acid. The great majority of gout cases are caused by under-excretion of uric acid, as a consequence of renal dysfunctions.
Although hyperucemia (high levels of serum uric acid) is considered to be directly related with the development of gout, the disease isnt always caused by this factor. For instance, people may develop gout even on the premises of normal serum uric acid levels, while many people with hyperucemia dont actually develop gout. Although the symptoms of gout closely resemble the clinical manifestation of rheumatoid arthritis, there doesnt seem to be a connection between...
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