Few drug-based treatments of obstructive sleep apnea are known despite over two decades of research and tests.
Oral administration of the methylxanthine theophylline (chemically similar to caffeine) can reduce the number of episodes of apnea, but can also produce side effects such as palpitations and insomnia. Theophylline is generally ineffective in adults with OSA, but is sometimes used to treat Central Sleep Apnea, and infants and children with apnea.
In earlier years, some neuroactive drugs, particularly a couple of the modern-generation antidepressants including mirtazapine, have been reported to reduce incidences of obstructive sleep apnea. As of 2004, these are not yet frequently prescribed for OSA sufferers.
When other treatments do not completely treat the OSA, drugs are sometimes prescribed to treat a patient’s daytime sleepiness or somnolence. These range from stimulants such as amphetamines to modern anti-narcoleptic medicines.
In some cases, weight loss will reduce the number and severity of apnea episodes, but for most patients overweight is an aggravating factor rather than the cause of OSA. In the morbidly obese a major loss of...