Nothing makes working from a home office more frustrating than not being able to find anything when you need it. While most business owners see themselves as being busy all the time, some of your time has to be spent in staying organized. If not daily, at least once a week you have to set aside time to put everything in its place. Most mechanics have a rule that there is a place for everything and everything needs to be in its place.
Many people have to find the time to do things over, but seldom have the time to do it right the first time. Usually because they cant find a file, they will have to recreate it, which will take a lot more time than the five seconds it might have taken to put it in its right place to begin with. Being able to find the staples when your stapler runs out can save a precious few minutes you will spend going through the desk drawers, or worse going to the store to buy more, knowing you have a new box somewhere in the office.
The amount of office supplies you maintain in the home office will depend on the business as well as your budget. Regardless, dont let your desk become a storage area for your supplies. Use an old dresser of bookcase...