Fosamax is a bisphosphonate drug used for osteoporosis and several other bone diseases. It is marketed alone as well as in combination with vitamin D under the name Fosavance.
Side-effects
GI tract: most prominent are harmless side effects such as mild nausea, dyspepsia, abdominal cramps, flatulence, diarrhea, or obstipation. A severe side effect is an ulceration of the esophagus caused by alendronate, which may require hospitalization and intensive treatment. Gastric and duodenal ulceration.
General: infrequent cases of skin rash, rarely manifesting as Stevens-Johnson syndrome and toxic epidermal necrolysis, eye problems (uveitis, scleritis) and generalized muscle, joint, and bone pain (rarely severe) have been seen. In laboratory tests decreased calcium and phosphate values may be obtained but reflect action of the drug and are harmless.
Osteonecrosis of the jaw, a recognised side-effect of bisphosphonates.
Dosage
Prophylaxis of osteoporosis in women: 5-10mg daily or 35-70mg weekly.
Therapy of osteoporosis in women and men : 10mg daily or 70mg weekly.
Osteoporosis under corticosteroids: 5mg daily or 35mg weekly in...
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